Sönmez, FatihSevmezler, SedatAtahan, AlparslanCeylan, MustafaDemir, DuduGencer, NahitKüçükislamoğlu, Mustafa2020-05-012020-05-0120110960-894X1464-3405https://doi.org/10.1016/j.bmcl.2011.09.130https://hdl.handle.net/20.500.12684/6366Gencer, Nahit/0000-0001-7092-8857WOS: 000297150600048PubMed: 22055203A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.en10.1016/j.bmcl.2011.09.130info:eu-repo/semantics/closedAccessChalconesTyrosinase inhibitorsArticle212474797482WOS:000297150600048Q2Q2