Yavas, Mehmet CihanKilitci, AsumanYegin, KorkutOruç, SinemDelen, KevserSirav, Bahriye2023-07-262023-07-2620222147-2092https://doi.org/10.12996/gmj.2022.77https://hdl.handle.net/20.500.12684/12563Introduction: The widespread access of the society to mobile phones and their intensive use cause health concerns. This study is aimed to investigate the possible histopathological effects of exposure to Radio-frequency Radiation (RFR) originating from mobile phones rat heart and spleen tissue. Methods: Totally 14 Sprague Dawley male rats were used and divided into 2 group (n= 7 for each); sham-control group, exposure group. RFR exposure group was exposed to 2100 MHz GSM-like RFR for 5 hours/day, for 14 days. Heart and spleen tissues of all rats were sampled for histopathological examination and hematoxylin-eosin staining was performed. For p53 examination, immunohistochemical staining was also used in both tissues. Results: Histopathological and immunohistochemical evaluation revealed no significant changes in heart tissue, but trabecular irregularity and enlargement of sinusoids were observed in the spleen in histopathological evaluation. Conclusion: It was observed that short-term RFR exposure did not cause significant morphological changes in heart and spleen tissue. This situation may be seen due to the protective effect of the body against RFR.en10.12996/gmj.2022.77info:eu-repo/semantics/openAccessMobile Phone; Spleen; Radio-Frequency Radiation; Heart; Rat900-Mhz Electromagnetic-Field; Oxidative Stress Parameters; Prenatal Exposure; Morphology; MelatoninArticle334341+2-s2.0-85140332264WOS:000863207700005Q4N/A