Aykanat, ÖmerKarakoyun, Durmuş OğuzTürkoğlu, Mehmet ErhanDinç, Cem2020-04-302020-04-3020171306-696Xhttps://doi.org/10.5505/tjtes.2016.43692https://hdl.handle.net/20.500.12684/2732WOS: 000403589400001PubMed: 28530785BACKGROUND: To study the anti-edematous, anti-inflammatory, and neuroprotective effect of etanercept in the model of experimental head injury. METHODS: In this study, 40 male-adult Spraque-Dawley rats, with weight ranging from 250g to 300g, were used. The rats are divided into groups as control; non-penetrating trauma; trauma + NS; post-traumatic normal saline; trauma + D; post-traumatic dexamethasone and trauma + E. All medicines were given into peritoneum. After applying trauma and medicine, rats were decapitated in the 24th hour and the samples were studied histopathologically. RESULTS: In the study, a statistically significant difference was observed between the groups of trauma + NS and trauma dexamethasone according to the variables of edema and inflammation, but no difference was observed according to the variables of neuronal damage, astrocytic damage, and glial apoptosis. Moreover, a significant difference was observed between groups of Trauma + NS and trauma+ etanercept and between the groups of trauma + dexamethasone and trauma + etanercept in terms of all variables. CONCLUSION: It was observed that etanercept has anti-edematous, anti-inflammatory, and neuroprotective effect on the rats which experienced traumatic brain injury.en10.5505/tjtes.2016.43692info:eu-repo/semantics/openAccessBrain edemaetanercepthead injuryArticle233173180WOS:000403589400001Q2Q4