Kurt, Akif HakanOlutas, Elif BernaAvcioglu, FatmaKarakus, HamzaSungur, Mehmet AliOztabag, Cansu KaraYildirim, Muhammet2024-08-232024-08-2320232190-4286https://doi.org/10.3762/bjnano.14.31https://hdl.handle.net/20.500.12684/13790The presented study comprises the one-pot synthesis and the characterization of quercetin-and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q-and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q-and Ch/CA-Ag NPs has been confirmed by ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q-and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the colloidal core Ag NPs, was confirmed by UV-vis, and FTIR analyses, and moni-tored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q-and Ch/CA-Ag, respec-tively. The anticancer activity of Ch/Q-and Ch/CA-Ag NPs has been evaluated against U-118 MG (human glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q-and Ch/CA-Ag NPs against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found.en10.3762/bjnano.14.31info:eu-repo/semantics/openAccessAg NPsanticancer and antibacterial effectscaffeic acidchitosanone-pot synthesisquercetinU-118 MG and ARPE-19 cellsDressing In-VitroAntioxidant ActivityCell-ProliferationChlorogenic AcidVivoBiodistributionNanocompositesInflammationAntitumorToxicityArticle14362376369982412-s2.0-85153768953WOS:000956622700001Q2Q2