Coşkun, AbdurrahmanBalbay, Öner AbidinDuran, SadıkAnnakkaya, Ali NihatBulut, İsmetYavuz, ÖzlemKurt, Emel2020-04-302020-04-3020070741-238Xhttps://doi.org/10.1007/BF02849905https://hdl.handle.net/20.500.12684/4197Coskun, Abdurrahman/0000-0002-1273-0604; Annakkaya, Ali Nihat N/0000-0002-7661-8830WOS: 000247571900017PubMed: 17565927Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1 +/- 5.0 mU/L) were higher than those of the control group (4.9 +/- 2.1 mU/L) (P <.01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581; P <.01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.en10.1007/BF02849905info:eu-repo/semantics/closedAccessasthmaatherosclerosisIGFIGFBP-4PAPP-AArticle242362367WOS:000247571900017Q1Q4