Demirci, TunaÖzdemir, OğuzhanKaya, Mustafa OğuzhanArslan, Mustafa2021-12-012021-12-0120211301-40482147-835Xhttps://doi.org/10.16984/saufenbilder.688414https://app.trdizin.gov.tr/makale/TkRJd01qWTNOdz09https://hdl.handle.net/20.500.12684/9630Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesizedand their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives inbasic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were synthesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysisof the compounds. The half maximal inhibitory concentration (IC50) values of the compoundswere determined to be between 27.03 and 104.39 ?M for hCA II and 19.85-76.64 ?M for Ki.en10.16984/saufenbilder.688414info:eu-repo/semantics/openAccess[No Keywords]Article251200211