Gümrükçüoğlu, NurhanSökmen, Bahar BilginŞahin, HüseyinUğraş, SerpilSağkal, YaseminUğraş, Halil İbrahim2020-04-302020-04-3020160253-5106https://hdl.handle.net/20.500.12684/4725Sahin, Huseyin/0000-0002-6018-1494WOS: 000390364000016Acylhydrazone 2 was synthesized by the condensation of iminoester hydrochloride 1 with acyl hydrazine. The treatment of acylhydrazone with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazole 3. The treatment of compound 3 with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3, 5-dialkyl-1,2,4-triazoles 4a-c. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl- 1,2,4-triazoles 5a-c. The obtained products were identified by FTIR, H-1-NMR, C-13-NMR, Mass spectroscopic and elemental analysis. A series of compounds were evaluated for their, antibacterial, antiurease, antioxidant activities. The results showed that the synthesized new compounds had effective antibacterial, antioxidant, antiurease activities.eninfo:eu-repo/semantics/closedAccess1,2,4-triazoleSchiff baseReductionUrease inhibition activityAntioxidant activityArticle385928936WOS:000390364000016Q4Q4