Aytekin, Cafer ErmanTurhan, YalcinKaraduman, Zekeriya OkanArican, MehmetSaglam, SonmezCoskun, Sinem KantarciogluUludag, Veysel2024-08-232024-08-2320241471-2474https://doi.org/10.1186/s12891-024-07694-6https://hdl.handle.net/20.500.12684/14067Purpose In this study, we aimed to investigate the effects of hyperbaric oxygen therapy and enoxaparin sodium, which are known to accelerate bone tissue healing as well as tendon and soft tissue healing, on the healing of Achilles tendon rupture. Methods Thirty-six rats were used in the present study. All rats were divided into groups of nine. The groups were the enoxaparin sodium group, enoxaparin sodium and hyperbaric oxygen group, hyperbaric oxygen group and control group. After 21 days, the process was completed, and the rats were sacrificed. Achilles tendon samples were evaluated histopathologically. Results The groups were compared according to the results of statistical analysis based on the histopathological data. There was no significant difference between the groups in terms of acute inflammation (p = 0.785) or chronic inflammation (p = 0.827) scores, but there were significant differences in neovascularization (p = 0.009), proliferation (p < 0.001) and fibrosis (p = 0.006) scores. Conclusion Our study showed that the use of enoxaparin sodium and hyperbaric oxygen had a positive effect on the healing of the Achilles tendon. Based on these results, we believe that the use of enoxaparin sodium and hyperbaric oxygen therapy after Achilles tendon rupture will be beneficial for healing and preventing complications.en10.1186/s12891-024-07694-6info:eu-repo/semantics/openAccessAchilles tendon ruptureHyperbaric oxygen therapyEnoxaparin sodiumRatRepairTendinopathyRegenerationHeparinArticle251390203582-s2.0-85198831235WOS:001271949300002Q2N/A