Karapolat, SamiGezer, SuatYıldırım, ÜmranDumlu, TalhaKarapolat, BanuÖzaydın, İsmetSarıtaş, Ayhan2020-04-302020-04-3020111749-8090https://doi.org/10.1186/1749-8090-6-14https://hdl.handle.net/20.500.12684/4223Saritas, Ayhan/0000-0002-4302-1093;WOS: 000287657700001PubMed: 21303502Background: Carbon dioxide (CO(2)) pneumoperitoneum facilitates the visualization of abdominal organs during laparoscopic surgery. However, the associated increase in intra-abdominal pressure causes oxidative stress, which contributes to tissue injury. Objective: We investigated the ability of the antioxidant and anti-inflammatory drug Erdosteine to prevent CO(2) pneumoperitoneum-induced oxidative stress and inflammatory reactions in a rat model. Methods: Fourteen female adult Wistar albino rats were divided into a control group (Group A, n = 7) and an Erdosteine group (Group B, n = 7). Group A received 0.5 cc/day 0.9% NaCl, and Group B received 10 mg/kg/day Erdosteine was administered by gavage, and maintained for 7 days prior to the operation. During the surgical procedure, the rats were exposed to CO(2) pneumoperitoneum with an intra-abdominal pressure of 15 mmHg for 30 min. The peritoneal gas was then desufflated. The rats were sacrificed following 3 h of insufflation. Their lungs were removed, histologically evaluated, and scored for intra-alveolar hemorrhage, alveolar edema, congestion, and leukocyte infiltration. The results were statistically analyzed. A value of P < 0.05 was considered statistically significant. Results: Significant differences were detected in intra-alveolar hemorrhage (P < 0.05), congestion (P < 0.001), and leukocyte infiltration (P < 0.001) in Group A compared with Group B. However, the differences in alveolar edema were not statistically significant (P = 0.698). Conclusions: CO(2) pneumoperitoneum results in oxidative injury to lung tissue, and administration of Erdosteine reduces the severity of pathological changes. Therefore, Erdosteine may be a useful preventive and therapeutic agent for CO(2) pneumoperitoneum-induced oxidative stress in laparoscopic surgery.en10.1186/1749-8090-6-14info:eu-repo/semantics/openAccessArticle6WOS:000287657700001Q2Q3