Mutlu, Esra CanseverYıldırım, Arzu BirinciYıldırım, MuhammetFicai, AntonFicai, DenisaOktar, Faik NüzhetDemir, Arzu2020-04-302020-04-3020190170-0839https://dx.doi.org/10.1007/s00289-019-02937-2https://hdl.handle.net/20.500.12684/359This study aims the improvement of antibacterial and biocompatibility properties of electrospray ternary blends of chitosan/poly(ethylene glycol)/hyaluronic acid. It conserves microscale particle structure even after incorporating zinc oxide (ZnO), the zeolite Mobil Composition of Matter No. 41 (MCM41) and penicillin G during this technique. Three different electrospray (ESP) blend compositions (ESPI, ESPII and ESPIII) have been produced in order to improve both antibacterial activity against to both gram-positive and gram-negative bacteria and biocompatibility. Results of FTIR spectroscopy and microscopy verified with SEM, EDS and AFM analyses. Hyaluronic acid surface has been specified definitely through ZnO-based ESPI surface composed of heterogeneously dispersed microparticles. Surface structures of ESPII and ESPIII have more homogenously dispersed microparticles as hill–valley surface by the aid of MCM 41-PEN. Antibacterial activity has been performed by Kirby–Bauer method. ESPI has good antibacterial activity against both gram-positive (S. aureus and S. epidermidis) and gram-negative bacteria (E. cloacea). Each electrospray film displayed good biocompatibility against to mouse fibroblast cell line L929 (ATTC number CCL-1). The highest amount of cell proliferation has been detected on ESPIII surface. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.en10.1007/s00289-019-02937-2info:eu-repo/semantics/closedAccessElectrospray; HA; MCM 41; Microparticles; ZnOArticleN/A