Başar, CengizBeşli, FeyzullahTürker, YasinÖzhan, Hakan2020-04-302020-04-3020151359-52371473-5725https://doi.org/10.1097/MBP.0000000000000131https://hdl.handle.net/20.500.12684/5239WOS: 000361477800003PubMed: 25968094BackgroundSerum uric acid (SUA) is an independent predictor of cardiovascular events in patients with hypertension. Total atrial conduction time (TACT) is a novel echocardiographic parameter used to identify the presence of electrical and structural atrial remodeling. We hypothesized that elevated SUA levels may be associated with prolonged TACT.MethodsA total of 50 consecutive hyperuricemic (defined as SUA>7mg/dl for men and >6.0mg/dl for women) patients who had hypertension were included in the study. A total of 42 normouricemic patients were also recruited consecutively as the control group. All patients were evaluated by two-dimensional echocardiography and TACT was estimated by measuring the time delay between the onset of the P-wave of ECG and peak A'-wave on the tissue Doppler imaging (TDI) of the left atrial lateral wall (PA-TDI duration).ResultsThere were no significant differences between the two groups according to age, sex, left ventricular systolic function, left atrial diameter, and systolic and diastolic blood pressure values. PA-TDI duration was found to be significantly increased in the hyperuricemic group (112.314.7 vs. 92 +/- 12.7ms; P<0.001) and positively correlated with the mean value of SUA levels (r=0.48, P<0.001).ConclusionTACT increases in patients with hyperuricemia. Certainly, larger studies in different populations should further examine this potential association.en10.1097/MBP.0000000000000131info:eu-repo/semantics/closedAccessatrial conduction timeatrial fibrillationhypertensiontissue Doppler echocardiographyuric acidArticle205249253WOS:000361477800003Q2Q4