Albayrak, MustafaKarataş, AhmetDemiraran, YavuzErman, HayriyeTopuz, SerenBıyık, İsmailErkan, Müşerref2020-05-012020-05-0120131476-70581476-4954https://doi.org/10.3109/14767058.2013.766699https://hdl.handle.net/20.500.12684/6101Uzun, Hafize/0000-0002-1347-8498WOS: 000319130800005PubMed: 23330872Objective: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). Methods: Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p <= 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p <= 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. Conclusion: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.en10.3109/14767058.2013.766699info:eu-repo/semantics/closedAccessGhrelinhyperemesis gravidarumleptinPYY-3Article269866870WOS:000319130800005Q2Q4