Baba, DursunDilek, Ismail EyupBasaran, EkremSenoglu, YusufBalik, Ahmet YildirimTaskiran, Arda TaskinYuksel, Alpaslan2025-10-112025-10-1120252148-9580https://doi.org/10.4274/jus.galenos.2025.2024-9-10https://search.trdizin.gov.tr/tr/yayin/detay/1316399https://hdl.handle.net/20.500.12684/21501Objective: This study aims to evaluate the efficacy and safety of retrograde intrarenal stone surgery (RIRS), mini-percutaneous nephrolithotomy (miniPCNL), and PCNL in patients with 1-2 cm kidney stones who failed extracorporeal shock wave lithotripsy (ESWL). Materials and Methods: This prospective study analyzed the medical records of 90 patients who underwent RIRS (n=29), miniPCNL (n=31), or PCNL (n=30) after unsuccessful ESWL treatment. The groups were compared based on operative time, hospital stay, complication rates, narcotic analgesic use, catheterization requirements, perioperative hemoglobin changes, transfusion needs, and treatment efficacy. Statistical analyses were performed using appropriate methods based on variable distribution. Results: RIRS resulted in significantly shorter hospital stays than miniPCNL and PCNL groups (p<0.001). MiniPCNL patients also had a shorter hospital stay than those in the PCNL group (p=0.047). The shortest operative time was observed in the PCNL group (59.9 min) compared to both the RIRS and miniPCNL groups (p<0.05). However, PCNL was associated with significantly higher narcotic analgesic use, greater hemoglobin reduction, and longer hospitalization. No significant differences were found among the three groups regarding transfusion requirements, residual stone rates, or overall complications. Conclusion: All three surgical methods were effective and safe for treating kidney stones measuring 1-2 cm in patients who previously failed ESWL. However, considering the shorter hospital stay and lower complication rates, RIRS and miniPCNL may be preferable options, while PCNL should be considered in selected cases.en10.4274/jus.galenos.2025.2024-9-10info:eu-repo/semantics/openAccessESWLkidney stoneminiPCNLpercutaneous nephrolithotomyRIRSArticle12279861316399WOS:001502480500001N/A