Büyükkaya, RamazanBüyükkaya, AylaAltunkaş, AyşegülErdoğmuş, BeşirYazıcı, BurhanÖztürk, BeyhanAnkaralı, Handan2020-04-302020-04-3020141302-87231308-0032https://doi.org/10.5152/akd.2014.4705https://hdl.handle.net/20.500.12684/2962Ankarali, Handan Camdeviren/0000-0002-3613-0523WOS: 000338109400014PubMed: 24818628Objective: In this study, we aimed to research the relation between breast arterial calcifications (BACs) detected on mammography and two well-known markers of cardiovascular diseases-carotid artery intima-media thickness (C-IMT) and haemodynamics parameters like carotid peak-systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI). Methods: The study group consisted of 50 consecutive BAC (+) women and the control group consisted of 55 BAC (-) women. In all participants, BAC was diagnosed using mammography and C-IMT was measured using B-mode and Doppler ultrasonography. BAC was defined as two linear calcification depositions in a conical periphery or as calcific rings at the mammographic evaluation. Doppler spectrum samples were obtained from 2 cm proximal to the main carotid artery bifurcation. Results: Postmenopausal female patients ranging in age from 40 to 86 included in this study. When the groups were adjusted for age, a statistically significant difference was found between mean C-IMT of BAC (+) and BAC (-) groups (0.81 +/- 0.2 vs. 0.69 +/- 0.2 mm; p<0.001). No significant differences were observed between BAC (+) and BAC (-) groups in terms of PSV, EDV, RI. Conclusion: The findings of the present study suggest that BAC, diagnosed by mammography, is independently associated with C-IMT. C-IMT measurement is suggested as a useful tool to detect early atherosclerotic changes. However, haemodynamic variables (PSV, EDV, RI) were not statistically different between the BAC (+) and BAC (-) groups. Prospective larger cohort studies are needed to further elucidate whether BAC is an independent risk factor for cardiovascular disease.en10.5152/akd.2014.4705info:eu-repo/semantics/closedAccessatherosclerosisbreast calcificationintima-media thicknessDoppler ultrasonographyArticle144378382WOS:000338109400014N/AQ4