Şahin, DuyguÖzgür, ElçinGüler, GülnurTomruk, ArınÜnlü, İlhanDinçel, Aylin SepiciSeyhan, Nesrin2020-04-302020-04-3020160891-06181873-6300https://doi.org/10.1016/j.jchemneu.2016.01.002https://hdl.handle.net/20.500.12684/4769Tomruk, Arin/0000-0002-7600-0811; Ozgur-Buyukatalay, Elcin/0000-0001-6428-918XWOS: 000381842500008PubMed: 26775761We aimed to evaluate the effect of 2100 MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone on the brain of rats during 10 and 40 days of exposure. The female rats were randomly divided into four groups. Group I; exposed to 3G modulated 2100 MHz RFR signal for 6 h/day, 5 consecutive days/wk for 2 weeks, group II; control 10 days, were kept in an inactive exposure set-up for 6 h/day, 5 consecutive days/wk for 2 weeks, group III; exposed to 3G modulated 2100 MHz RFR signal for 6 h/day, 5 consecutive days/wk for 8 weeks and group IV; control 40 days, were kept in an inactive exposure set-up for 6 h/day, 5 consecutive days/wk for 8 weeks. After the genomic DNA content of brain was extracted, oxidative DNA damage (8-hydroxy-2'deoxyguanosine, pg/mL) and malondialdehyde (MDA, nmoL/g tissue) levels were determined. Our main finding was the increased oxidative DNA damage to brain after 10 days of exposure with the decreased oxidative DNA damage following 40 days of exposure compared to their control groups. Besides decreased lipid peroxidation end product, MDA, was observed after 40 days of exposure. The measured decreased quantities of damage during the 40 days of exposure could be the means of adapted and increased DNA repair mechanisms. (C) 2016 Elsevier B.V. All rights reserved.en10.1016/j.jchemneu.2016.01.002info:eu-repo/semantics/closedAccess2100MHz radiofrequency radiationMobile phone radiationBrainDNA oxidative damageLipid peroxidationArticle759498WOS:000381842500008Q4Q3