Nisari, MustafaEröz, Recep2021-12-012021-12-0120201300-01441303-6165https://doi.org/10.3906/sag-2003-251https://app.trdizin.gov.tr/makale/TXpVME56UXpNdz09https://hdl.handle.net/20.500.12684/9616Background/aim: To determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinomaderivate from colon cancer (Caco-2 cell).Materials and methods: In this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as controland different capsaicin exposed doses (25uµ, 50uµ, and 75uµ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA)were calculated.Results: A significant differences were detected between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin (75uµ)(P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.001) and between capsaicin (25uµ) and capsaicin (75uµ) (P = 0.000)for TAA/NA. Also, there were significant differences between control and capsaicin (50uµ) (P = 0.001), between control and capsaicin(75uµ) (P = 0.000), between capsaicin (25uµ) and capsaicin (50uµ) (P = 0.000) and between capsaicin (25uµ) and capsaicin (75uµ) (P= 0.000) for mean AgNOR number.Conclusion: A certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations areimportant for the most reliable treatment.en10.3906/sag-2003-251info:eu-repo/semantics/openAccess[No Keywords]Article50410761081324906512-s2.0-85090725320WOS:000613005100056Q3Q4