Barışçı, SibelTürkay, ÖzgeUlusoy, EbruŞeker, Mine GülYüksel, EbubekirDimoglo, Anatoli2020-05-012020-05-0120181385-89471873-3212https://doi.org/10.1016/j.cej.2017.11.105https://hdl.handle.net/20.500.12684/6218Barisci, Sibel/0000-0003-4229-0408; Dinc, Ozge/0000-0002-3029-7840WOS: 000418533400181Methotrexate (MTX) and Capecitabine (CPC) as mostly used cytostatic drugs were degraded by electro-oxidation process in this study. Ti/IrO2-RuO2 electrode was used to provide anodic oxidation. The effect of change of current density, initial pH of the solution and supporting electrolyte concentration on electro-oxidation of cytostatic drugs was evaluated. Current density of 30 mA/cm(2), neutral pH and supporting electrolyte concentration of 200 mg L-1 were determined as optimum operational parameters. After oxidation process, the transformation by-products of cytostatic drugs were identified by LC-MS-MS analysis. Density functional theory (DFT) modelling was performed and the calculations were given in harmony with analytic results. In addition, toxicity evaluation on the electro-oxidation was assessed due to the possible toxic effect of the metabolites after treatment process. Indeed, the transformation by-products of MTX showed toxic effects after treatment, however; the metabolites CPC did not cause toxicity although lower removal efficiency.en10.1016/j.cej.2017.11.105info:eu-repo/semantics/closedAccessCapecitabineCytostaticElectro-oxidationMethotrexateToxicityDFT modellingArticle33418201827WOS:000418533400181Q1Q1