Demiraran, YavuzÖztürk, ÖzcanGüçlü, Enderİskender, AbdülkadirErgin, Mehmet HakanTokmak, Abdurahman2020-04-302020-04-3020080003-2999https://doi.org/10.1213/ane.0b013e31816174c3https://hdl.handle.net/20.500.12684/5349WOS: 000253393900050PubMed: 18292454BACKGROUND: In this study, we compared the use of preincisional liclocaine 2% with epinephrine (LA) and levobupivacaine 0.25% plain (LB) for postoperative analgesia and vasoconstriction in patients undergoing nasal surgery. METHODS: Sixty patients were randomly assigned to receive preincisional local infiltration under general anesthesia. Group LB received levobupivacaine 0.25%, and group LA received epinephrine plus liclocaine 2% (add volume injected). Intraoperative hemodynamic changes, pre- and postoperative hemoglobin and hematocrit values were recorded. Visual analog scale values 30 min and 1, 2, 8, 12, and 24 h postoperatively and the need for rescue analgesic treatment in the first 24 h of all patients was recorded. RESULTS: At 30 min and 1, 2, 8, and 12 h postoperatively, visual analog scale values were lower in group LB than in group LA (P < 0.0001, P = 0.002, P = 0.023, P < 0.0001, and P = 0.011, respectively). The analgesic requirement was significantly lower in group LB when compared with that in group LA (P = 0.038). Group LB had significant differences between preoperative and postoperative hemoglobin and hematocrit values (P = 0.014 and 0.025). Group LA had significant differences between preoperative and postoperative hemoglobin and hematocrit values (P 0.031 and 0.024). CONCLUSIONS: We conclude that postoperative analgesia in nasal surgery with local infiltration of levobupivacaine was significantly more potent and longer lasting than that achieved by lidocaine plus epinephrine.en10.1213/ane.0b013e31816174c3info:eu-repo/semantics/closedAccessArticle106310081011WOS:000253393900050N/AQ2