Çelik, SamettinÇalışkan, Canan S.Çelik, HandanGüçlü, MehmetBaşbuğ, Alper2020-04-302020-04-3020190017-00112543-6767https://doi.org/10.5603/GP.2019.0039https://hdl.handle.net/20.500.12684/4182WOS: 000466963400008PubMed: 31059115Objectives: Our objective was to evaluate in our clinic the perinatal outcomes of patients diagnosed with ICP based on pre-treatment maternal serum bile acid levels, attempt to identify the risk group and review the literature in light of this information. Material and methods: In total, 370 patients diagnosed with ICP were included in the study, divided into two groups based on the fasting total serum bile acid level before UDCA (Group 1: 10 >= 40 mu mol/L, and Group 2: >= 40 mu mol/L). The groups were examined for clinical characteristics and pregnancy outcomes. Results: It was found that preterm delivery and neonatal intensive care need increased at a serum bile acid cut-off value of 34 mu mol/L. Regardless of serum bile acid, significantly higher rates of meconium-stained amniotic fluid and foetal distress were observed in patients whose diagnoses were made before 34 weeks of gestation. Conclusions: Foetal complications over 40 mu mol/L of serum bile acid were significantly increased. However, slightly lower levels cut-off values (34 mu mol/L) were obtained in terms of preterm birth and neonatal intensive care need. The incidence of meconium-stained amniotic fluid and foetal distress was higher in patients whose diagnosis were made before 34 weeks of gestation.en10.5603/GP.2019.0039info:eu-repo/semantics/openAccessintrahepatic cholestasispregnancyperinatal complicationsArticle904217222WOS:000466963400008Q3Q4