Kurt, FatihEroz, RecepKocabay, Kenan2024-08-232024-08-2320231309-3878https://doi.org/10.18521/ktd.1162175https://search.trdizin.gov.tr/tr/yayin/detay/1160766https://hdl.handle.net/20.500.12684/13944Objective: This study was carried out to compare the expression levels of ASC(Apoptosis Associated Speck Like Protein Containing a CARD), TL-1a(TNF Like Factor 1a) and CXCL 13(B Cell Chemoattractant Chemokine Ligand 13) genes in FMF patients According to Tell-Hashomer Criteria and Genetic analysis result in Duzce University Research and Application Hospital with healthy controls and to determine their clinical significance in FMF.Method: 36 patients (20 girls, 16 boys) and 12 healthy controls (7 girls, 5 boys) were included in the study. RNA was isolated from the peripheral blood of each individual and expression levels of ASC, TL-1a and CXCL 13 genes were determined. Routine biochemical parameters were also determined.Results: CXCL 13 and TL-1a gene expression levels were significantly increased in patients with FMF, the expression level of the ASC gene was found to be increased in FMF patients, but not significantly.Conclusion: The expression levels of these genes may be related to the pathogenesis of the disease and these genes could be used as a marker in the early diagnosis of the disease.en10.18521/ktd.1162175info:eu-repo/semantics/openAccessFMFASCCXCL13TL-1aNitric-OxideGeneMutationAmyloidosisDeletionRiskArticle15159681160766WOS:000957966500008Q3