Çelik, ÖnderHatırnaz, ŞafakErşahin, AynurBaşbuğ, AlperYıldırım, Gonca YetkinÖzener, VahitÜnlü, Cihat2021-12-012021-12-0120201309-03991309-0380https://app.trdizin.gov.tr/makale/TXpZME9ETTNOdz09https://hdl.handle.net/20.500.12684/9805Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicularsperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA).Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previousmicro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopysequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively andcompared with the results of the micro-TESEs.Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. Ahigh Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showeda marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value ofCr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm.Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE. (J Turk GerGynecol Assoc 2020; 21: 70-8)eninfo:eu-repo/semantics/openAccess[No Keywords]Article2127078WOS:000540310000002N/A