Güler, MesutUslu, MustafaTürkeli, ErdinçŞeramet, EbubekirDoğan, Ali2020-04-302020-04-3020121307671Xhttps://hdl.handle.net/20.500.12684/670Purpose: This study is performed to identify the effect of iliprost on joint synovium and cartilage. Material and method: In this study histopathological evaluation of iloprost effects on knee joint synovium and cartilage are determined on young male Spraque-Dawley rats. Twenty rats divided into four groups, each consisted five rats. 0.1 ml iloprost enjected into right knees and 0.1 ml SF enjected into left knees of all rats. The groups are sacrificed randomly on first, seventh, fourteenth and twentyfirst days. Knee specimens are taken including femoral condyles, tibial platos and capsules for histopathological evaluation. Result:At the end of the histopathological evaluation, there was significant difference between the knees iloprost injected group and SF injected, control group. İn the early sacrifeced iloprost group, inflammation on joint cartilage and synovium is much more than late sacrifeced iloprost groups. İnflammation between the iloprost groups and SF control goups decreased time depentently. İn the synovial hyperplasia and synovial hypertrophy there was significant difference between the iloprost group and SF group and not changed time dependently. Conclusion:As intraarticular injected iloprost increased intraarticular inflammation we should decided not to give iloprost intraarticularly. İt is thought that systemic iloprost will have positive effects on osteoarthritic knees. © 2012 Düzce Medical Journal.eninfo:eu-repo/semantics/closedAccessCartilage; Iloprost; Knee joint; Rat; SynoviumArticle142814Q4