Çalışkan, EmelÖztürk, C.E.Ankaralı, Handan2020-04-302020-04-3020111307671Xhttps://hdl.handle.net/20.500.12684/382Objective:. In this study, beta-lactamase production and antibiotic susceptibility in some Gramnegative bacteria isolated in our hospital were investigated. Methods: The presence of inducible beta-lactamase by direct induction test, the presence of extended-spectrum beta-lactamase by double-disk synergy method were investigated. In-vitro susceptibility tests were performed by disk diffusion method, in the direction of the Clinical and Laboratory Standards Institute recommendations. Results: The rate of inducible beta-lactamase was found as 2 %, and the rate of extendedspectrum beta-lactamase as 8 %. Imipenem was the most effective antimicrobial. The rates of resistance to ampicillin, amoxicillin-clavulanic acid and ciprofloxacin were very high. Conclusion: Although, amikacin, gentamicin, sefoperazon-sulbactam, piperacillin-tazobactam can be used as alternatives to carbapenems in empirical treatment of nonserious infections in our hospital, ampicillin, amoxicillin-clavulanic acid and ciprofloxacin are not suitable for this purpose. © 2011 Düzce Medical Journal.eninfo:eu-repo/semantics/closedAccessAntibiotic resistance; ESBL; Gram-negative bacteria; IBLArticle1331317Q4