Güven, Damla GüçlüDemiraran, YavuzSezen, GülbinKepek, Ökkeşİskender, Abdülkadir2020-05-012020-05-0120110003-4894https://doi.org/10.1177/000348941112000906https://hdl.handle.net/20.500.12684/6371WOS: 000295199700006PubMed: 22032072Objectives: We aimed to evaluate the effects of dexmedetomidine hydrochloride (DEX) on hemodynamic parameters and on surgeon and patient satisfaction during functional endoscopic sinus surgery (FESS). Methods: Forty patients who were to undergo FESS were enrolled in this randomized, prospective, controlled study. In the DEX group, conscious sedation was induced with an infusion of 1 mu g/kg of DEX 10 minutes before surgery, followed by an infusion of DEX at 0.2 mu g/kg per hour. A control group was given identical amounts of saline solution. During the procedure, hemodynamic data were recorded. The patients evaluated their pain on a visual analog scale (VAS). Intraoperative bleeding was rated on a 6-point scale for evaluation of operative field visibility. Results: We observed that the DEX group had lower bleeding scores (p = 0.019). The heart rates were lower in the DEX group at the time of induction (p = 0.052) and in the 1st (p = 0.009) and 20th minutes (p = 0.039) of induction. The mean blood pressure values were lower in the DEX group in the 5th (p < 0.001), 45th (p = 0.003), and 60th (p = 0.05) minutes of induction. The VAS score was lower in the DEX group in the 30th postoperative minute (p = 0.001); however, the VAS score was lower in the control group after the 12th hour (p < 0.001). Postoperative side effects such as nausea, tachycardia, hypotension, and vomiting were significantly less frequent in the DEX group (p < 0.001). Conclusions: We observed that the intraoperative bleeding, hemodynamic stability, and VAS scores were better and the side effects were less frequent in the DEX group.en10.1177/000348941112000906info:eu-repo/semantics/closedAccessdexmedetomidineFESSfunctional endoscopic sinus surgeryhemodynamic stabilityintraoperative bleedingArticle1209586592WOS:000295199700006Q1Q3