Aghatabay, Naz MohammedParalı, ÖzgeZaim, ÖmerBaydar, ÇağlarDülger, Başaran2020-04-302020-04-3020141388-31271573-1111https://doi.org/10.1007/s10847-013-0364-4https://hdl.handle.net/20.500.12684/4740Dulger, Basaran/0000-0002-3184-2652; Zaim, Omer/0000-0002-3472-5611; Dulger, Basaran/0000-0002-3184-2652WOS: 000339274100016Four novel [2 + 2] condensed tetramide-tetrathioether cycloheterophane (L (1) -L (4) ), possessing thioether as ligating units have been prepared. The compounds were characterized by elemental analyses, mass, FT-IR, H-1, and C-13 NMR spectral data. The 24-membered macrocycles have well organized symmetrical structures lacking any configurational isomerism. Ion transportation was carried out with macrocycle L (1) and L (4) against Na+, K+ and Ag+ cations. It showed a high propensity of binding with soft Ag+ cation that it undergoes configurational change during complexation. This phenomenon is not observed with hard cations, but K+ ion passes through the cavity while Na+ ions are retained. The antimicrobial activities of the compounds were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration dilution method, against several bacteria and yeast cultures. The results were compared with those of commercial antibiotic and antifungal agents. Structure activity relationships were also discussed.en10.1007/s10847-013-0364-4info:eu-repo/semantics/closedAccessAntimicrobialCycloheterophaneDiffusionInhibitoryIon transportationYeastArticle7903.Apr415424WOS:000339274100016Q3Q2