Yıldırım, ÜmranErdem, HavvaKayıkçı, A.Şahin, A.F.Uzunlar, Ali KemalAlbayrak, A.2020-05-012020-05-0120100300-06051473-2300https://doi.org/10.1177/147323001003800514https://hdl.handle.net/20.500.12684/5449WOS: 000285404000014PubMed: 21309483This study was designed to investigate the protein levels of cyclooxyogenase-2 (COX-2) and survivin in superficial urothelial carcinoma (UC) and their correlation with microvessel density (MVD). High-grade UC was positive for both COX-2 and survivin protein, and the proportion of tumours positive for both proteins increased with increasing tumour grade. The presence of COX-2 protein was significantly correlated with the presence of survivin protein. Both COX-2 and survivin positivity were significantly correlated with MVD in all patients regardless of tumour grade, but there was no correlation between MVD and COX-2 and survivin positivity by individual tumour grade. Although there was no significant difference in the proportion of COX-2-positive tumours when patients were stratified by tumour stage, a significantly higher proportion of patients with pT1 stage tumours were survivin-positive compared with patients with pTa stage tumours. COX-2 and survivin positivity were significantly correlated in all patients regardless of tumour grade or stage. COX-2 and survivin were significantly correlated in patients with pTa, but there was no correlation in pT1 tumours. These findings demonstrate that together, COX-2, survivin and MVD may play an important role in UC.en10.1177/147323001003800514info:eu-repo/semantics/closedAccessUROTHELIAL CARCINOMACYCLOOXYOGENASE-2 (COX-2)SURVIVINCANCER GRADECANCER STAGEArticle38516891699WOS:000285404000014Q3Q4