Güçlü, EnderCoşkun, AbdurrahmanTokmak, AbdurrahmanDuran, SadıkÖztürk, ÖzcanAkkan, NerminEgeli, Erol2020-05-012020-05-0120081050-6586https://doi.org/10.2500/ajr.2008.22.3179https://hdl.handle.net/20.500.12684/5621Coskun, Abdurrahman/0000-0002-1273-0604WOS: 000256132300001PubMed: 18588751Background: Pregnancy-associated plasma protein A (PAPP-A), also known as insulin-like growth factor binding protein 4 protease, is postulated to be a new inflammatory marker in various clinical situations such as cardiovascular events, dialysis, renal transplantation, and asthma. PAPP-A also is produced in high concentrations by trophoblasts during pregnancy. Methods: We evaluated PAPP-A levels in allergic rhinitis patients and compared these with levels in healthy subjects. Thirty-one newly diagnosed allergic rhinitis patients and 29 healthy controls were included in the study. Serum PAPP-A, IgE, urea, creatinine, aspartate aminotransferase, creatine kinase (CK), CK-MB isoenzyme, total cholesterol, and triglyceride levels were determined. Results: The serum PAPP-A level was significantly higher (p = 0.013) in the allergic rhinitis group (6.1 +/- 2.9 mU/L) than in the control group (4.5 +/- 1.7 mU/L). The PAPP-A level in patients with allergic rhinitis and asthma (6.1 +/- 2.3 mU/L) was not significantly different (p = 0.959) from that in patients with allergic rhinitis alone (6.1 +/- 3.3 mU/L). The serum PAPP-A level in allergic rhinitis patients who had turbinate hypertrophy (6.9 +/- 2.2 mU/L) had a tendency to be higher than that in patients who had no turbinate hypertrophy (5.5 +/- 3.2 mU/L); however, this difference was not statistically significant (p = 0.151). Conclusion: Increased PAPP-A activity may be involved in the inflammation and tissue remodelling that occurs in allergic rhinitis.en10.2500/ajr.2008.22.3179info:eu-repo/semantics/closedAccessallergic rhinitishypervascularityIGFIGFBP-4inflammationmatrix metalloproteinasenasal mucosaPAPP-Apregnancytissue remodelingArticle223219222WOS:000256132300001N/AQ2