Alemdar, CelilYücel, İstemiErbil, BarışErdem, HavvaAtiç, RamazanÖzkul, Emin2020-05-012020-05-0120160019-54131998-3727https://doi.org/10.4103/0019-5413.185607https://hdl.handle.net/20.500.12684/5724OZKUL, EMIN/0000-0003-2149-8154WOS: 000381289600012PubMed: 27512224Background: The common purpose of almost all methods used to treat the osteochondral injuries is to produce a normal cartilage matrix. However current methods are not sufficient to provide a normal cartilage matrix. For that reason, researchers have studied to increase the effectiveness of this methods using chondrogenic and chondroprotective molecules in recent experimental studies. Insulin-like growth factor-1 (IGF-1) and hyaluronic acid (HA) are two important agents used in this field. This study compared the effects of IGF-1 and HA in an experimental osteochondral defect in rat femora. Materials and Methods: The rats were divided into three groups ( n = 15 per group) as follows: The IGF-1 group, HA group, and control group. An osteochondral defect of a diameter of 1.5 mm and a depth of 2 mm was created on the patellar joint side of femoral condyles. The IGF-1 group received an absorbable gelatin sponge soaked with 15 g/15 l of IGF-1, and the HA group received an absorbable gelatin sponge soaked with 80 g HA. The control group received only an absorbable gelatin sponge. Rats were sacrificed at the 6 (th) week, and the femur condyles were evaluated histologically. Results: According to the total Mankin scale, there was a statistically significant difference between IGF-1 and HA groups and between IGF-1 and control groups. There was also a significant statistical difference between HA and control groups. Conclusion: It was shown histopathologically that IGF-1 is an effective molecule for osteochondral lesions. Although it is weaker than IGF-1, HA also strengthened the repair tissue.en10.4103/0019-5413.185607info:eu-repo/semantics/openAccessCartilagehyaluronic acidinsulin-like growth factor-1osteochondral defect MeSH terms: Hyaluronic acidcartilageIGF-1sports medicineratsArticle504414420WOS:000381289600012Q3Q4