Karataş, AhmetErdem, HavvaAlbayrak, MustafaOktay, MuratÖzlü, TülayÇakmak, BülentDönmez, Melahat Emine2020-04-302020-04-3020141476-70581476-4954https://doi.org/10.3109/14767058.2013.833600https://hdl.handle.net/20.500.12684/2591oktay, murat/0000-0002-0893-4444;WOS: 000333583100007PubMed: 23941406Introduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control. We aimed to investigate the relationship between pendrin immunostaining intensity in normal and pre-eclamptic placental tissue. Methods: Fifty-six placental tissues, of which 26 were in pre-eclamptic, and 30 were in control group were evaluated by immunohistochemical staining. Positive immunostaining was evaluated using a semiquantitative score: 0, negative; +, mild; ++, moderate; and +++, intense. Results: There was more positive immunstaining in the pre-eclamptic placenta compared to the controls (p<0.001). A significant positive correlation was observed between immunostaining level and diastolic blood pressure (r = 0.533, p = 0.005) in the pre-eclamptic group. However, no significant correlation was observed between any condition and immunostaining level in the control group. Conclusions: Placentas in the pre-eclamptic group were significantly more immunostained with pendrin than were those in the control group. In addition, a positive correlation between immunostaining intensity with pendrin and both systolic and diastolic blood pressure were observed. Pendrin may play a role in the mechanism of severe hypertension in women with pre-eclampsia.en10.3109/14767058.2013.833600info:eu-repo/semantics/closedAccessPendrinplacentapre-eclampsiaArticle277687690WOS:000333583100007Q2Q3